Computational Flu Vaccine

The Reverse Vaccinology Approach


FutureFlu is utilizing bioinformatics tools and custom developed software to calculate the candidate seasonal vaccine for the upcoming flu season. For two years in a row, the computed vaccines have been a perfect match with those recommended later by the World Health Organization (WHO) and Centers for Disease Control (CDC).


FutureFlu has created a Fourier-enhanced Phylogeny/Antigenicity Predictive Model (F^P/A-PM) to calculate the seasonal flu vaccine. The mathematical model analyzes the historical influenza data using reverse vaccinology. Reverse vaccinology is the science of studying the dynamic patterns in the genomic data to select antigenic targets and to design vaccines. It blends computational biology with the conventional lab-based assays.

What's New

2018-03-01. The vaccine calculated by FutureFlu is once again a perfect match with the one announced by WHO/CDC. FutureFlu recommended changing the H3N2 vaccine to A/Slovenia/342/ 2017- like virus for the 2017-18 flu season and keeping the H1N1pdm unchanged. The recommendations by WHO/CDC are the same.